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July 19, 2022 By 0 comment

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Conclusions
===========

In conclusion, this study demonstrated that EGFR inhibitor AG1478 could downregulate EGFR-mediated NF-κB activation in PDAC cells. The inhibition of EGFR downstream signaling via EGFR/PI3K/AKT and Ras/RAF/MEK/ERK signaling pathways resulted in the transcriptional downregulation of NF-κB genes. This molecular suppression was accompanied by inhibition of PDAC cell growth, migration and invasion. Our findings indicate that dual inhibition of EGFR and NF-κB signaling is a promising strategy for PDAC therapy.

Abbreviations
=============

EGFR: epidermal growth factor receptor; PDAC: pancreatic ductal adenocarcinoma; PDGFR: platelet-derived growth factor receptor; Akt

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